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Stocks and Shares Isa (Santander) Advice for Dummies

I bank with Santander and I'm thinking of setting up this isa with them as my savings account is with them also. I'm thinking it'll be easier to transfer money to the isa, online, from the savings account. I saw that they have a £20 thing where they ask you questions about your views on risk taking etc. After that, what do they charge for each transaction? Eg, if I buy 10 shares from 10 companies each? How many transactions do I need to make each month or year? I;ll probably be buying shares, not selling but sell in 5 years. At that point I'll be around the age of 60. If I retire at 60, and then sell any shares, do I pay tax on the income? Will it affect my pension income? I've an nhs pension and can take it at 60 if I wish (there's a portion in the 2015 scheme which I'm best not touching at age 60).
Are there any do's and don'ts anyone can advise on?
I don't have any isa at the moment.

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