Programs not responding especially when using "save as"

Hello,

I can use Firefox and internet without problems but if I try to launch any other programme that programme either just freezes and won't launch (just says "not responding") (Eg: Cute FTP) or it will launch and open the file but when you try to save it the same thing happens (Eg: excel, word) or it will launch but when you try to open a file it stops responding (eg: Dosh cashbook; Paintshop Pro).

I did a disk cleanup of the C drive then defragged the PC - this worked for one day and then the problem came back :(

When the progs say not responding and I use Cntrl alt delete to try and close them nothing happens when I click end program.

ANti-Virus software is up to date and I have run SPybot and Adaware.
Hard drive is only about 20% full. PC is running Windows XP.

Obviously not being able to open any programs means that I can't get any work done! Any ideas of what is causing this? THanks.
"The happiest of people don't necessarily have the
best of everything; they just make the best
of everything that comes along their way."
-- Author Unknown --

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